The overall goals of this WP are:

1. The detection of small ligands that may bind too weakly to be identified by traditional means to the surface of humanTS that participates in the formation of the active dimeric form of the enzyme by using protein labelling tecniques.

2. The optimization of the binding of peptides that have been identified to bind to monomeric TS

3. Understand the regulatory mechanism relating the TS monomer-dimer balance and TS mRNA binding through protein mutagenesis and small-molecule perturbation

These objectives will be achieved by a combination of computational and experimental approaches.

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WP SCHEME